Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog.
نویسندگان
چکیده
Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.
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ورودعنوان ژورنال:
- Applied and environmental microbiology
دوره 75 9 شماره
صفحات -
تاریخ انتشار 2009